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. 2018 May 18;13:2943–2954. doi: 10.2147/IJN.S155052

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© 2018 Shabani et al. This work is published and licensed by Dove Medical Press Limited

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Physiochemical characterization and SEM and TEM analyses of CDDP/PLGA NPs.

Notes: (A) Sustain-release phenomenon exhibited by drug-loaded NPs in PBS with pH of 7.4 at 37°C. Initially, 30% of cisplatin was released, and after 48 hours, 70% of cisplatin was released. The values are shown as mean ± SD, n = 3. (B) Size of NPs was measured by DLS. (C) FTIR spectrum of CDDP/PLGA NPs. (D) Scanning electron micrographs of cisplatin-loaded PLGA NPs prepared with W/O/W method (bar: 1 μm). The blue H’s represent the width of the nanoparticles. (E) TEM analysis of drug-loaded NPs depicting the spherical nature of the nanocapsules (bar: 570 nm). The red arrows represent a completely dark center and the blue arrows show the bright margin of the nanoparticle, indicating the loaded drug and the environmental polymer.

Abbreviations: SEM, scanning electron microscopy; TEM, transmission electron microscopy; CDDP, cis-diaminedichloroplatinum; PLGA, poly(lactic-co-glycolic acid); NPs, nanoparticles; PBS, phosphate-buffered saline; DLS, dynamic light scattering; FTIR, Fourier transform infrared spectroscopy; W/O/W, water/oil/water.