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. 2018 May 18;13:2921–2942. doi: 10.2147/IJN.S158696

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© 2018 Zhou et al. This work is published and licensed by Dove Medical Press Limited

The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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(A) Preparation of nanocomplex PMLA-PEI-DOX-TAT@PEG-DMMA. (B) Schematic illustration of the dual pH-sensitive DOX-loading nanocomplex with the charge-conversional function for effective tumor-targeted drug delivery, enhanced cellular uptake, and intracellular drug release.

Notes: Reprinted from Zhou Q, Hou Y, Zhang L, et al. Dual-pH sensitive charge-reversal nanocomplex for tumor-targeted drug delivery with enhanced anticancer activity. Theranostics. 2017;7(7):1806–1819.³⁵ Creative Commons Attribution (CC BY-NC) license, available from: https://creativecommons.org/licenses/by-nc/4.0/

Abbreviations: PMLA, poly(β-l-malic acid); PEI, poly(ethylene imine); DOX, doxorubicin; TAT, trans-activating transcriptional activator; PEG, poly(ethylene glycol); DMMA, 2,3-dimethylmaleic anhydride.