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. 2018 May 18;11:2945–2954. doi: 10.2147/OTT.S165436

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© 2018 Wu et al. This work is published and licensed by Dove Medical Press Limited

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Triclosan promotes the metabolisms or clearances of sorafenib.

Notes: (A) MHCC97-H cells, pretreated with 1 μmol/L sorafenib for 12 hours, were treated with solvent control or 300 nmol/L triclosan. Cells were harvested at indicated time points. (B) MHCC97-H cells were used to form subcutaneous tumor. Sorafenib solution (Sor-Sol) was injected into tumor tissues, and mice were then treated with solvent or 500 μg/kg triclosan. Tumor tissues were harvested at indicated time points. The cell samples or tumor tissue samples were analyzed by LC-MS/MS to value the sustaining of sorafenib concentration. The sustaining curve is shown as mean ± SD. *P<0.05 solvent control group vs triclosan group.

Abbreviation: LC-MS/MS, liquid chromatography/mass spectrometry-mass spectrometry.