GSI treatment resulted in prominent necrosis of KSHV-positive lymphomas. (A) Tumor growth post BJAB, BCBL1, JSC1 cell transplantation in PEL/SCID mice. Tumor size of BJAB cell transplantation between GSItreated and mock-treated groups had no difference, and exhibited no cell necrosis in tumor tissues; however, tumor tissues of KSHV-positive both BCBL1 and JSC1 cell transplantation with GSI-treated group showed prominent necrosis (arrowed) (HE staining, low magnification). (B) Tumor cell growth of BJAB cell transplantation with GSI-treated and mock-treated groups were good, whereas tumors of BCBL1, JSC1 cell transplantation with GSI treatment group had prominent necrosis (HE stain ×400).