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Model showing GSI inhibition of PEL cells outgrowth in vivo. GSI slows down the proliferation of KSHV positive PEL cells in mice, therefore prolongs the life span of the treated mice. Mice transplanted with KSHV positive PEL cells showed an increased level of expansion of these cells in vivo resulting in death of the mice. However, mice treated with GSI which inhibits the production of ICN showed an increased survival compared to untreated mice.
