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MMP-2 in the TME promotes DC driven TH2 differentiation. MMP-2 derived from melanoma cells initiates two independent signaling cascades in DCs that cause TH2 polarization. (1) MMP-2 cleaves IFNAR1 on DCs, thus inhibiting Stat1 phopshorylation and downregulating IL12 secretion and (2) MMP-2 interacts with TLR-2 to activate canonical NFκB signaling and upregulate TH2-promoting OX40L
