. Author manuscript; available in PMC: 2018 May 23.

Published in final edited form as: Cancer Biol Ther. 2010 Nov 15;10(10):961–978. doi: 10.4161/cbt.10.10.13923

Table 1.

Tumor virus and associated cell-signaling molecules

Tumor virus	Viral genome	Viral oncoproteins^*	Important cellular binding partners	Deregulated signaling-pathways	Ref.
HPVs (16, 18)	DNA	E6	p53, p73, E6AP, CBP/p300, c-Myc	p53, cell-cycle	188

		E7	pRb, pRb pocket proteins, p21^CIP1, p27^KIP1, IRF-1, Cyclin A and E	pRb, cell-cycle, ub-proteasome	188

EBV	DNA	EBNA2	RBP-Jκ, PU.1, AUF1, DDX20, SMN	Notch, cellular transcription, metastasis	189, 190

		EBNA3C	p53, Mdm2, pRb, p300, RBP-Jκ, Chk2, Nm23-H1, c-Myc, HDAC1, SUMO-1, SUMO-3, SCF^Skp2-complex, DDX20, SMN, CtBP, Cyclin A, E and D1	Cell-cycle, Notch, ub-proteasome, metastasis, chromatin remodeling, cellular transcription, apoptosis, inflammation	31, 52, 60, 82, 99, 100, 128, 190, 191

		LMP1	TRAFs 1, 2, 3 and 5, TRADD, RAS, JAK	NFκB, cell-cycle, cellular transcription, apoptosis, inflammation, autophagy, metastasis, MAPK, PI3K/Akt, JAK/STAT, TNF	51, 75, 81, 98, 142, 147, 151, 152, 190, 192, 193

		LMP2	TNFR associated factors, RAS, JAK	Apoptosis, metastasis, MAPK, PI3K/Akt, JAK/STAT, TNF, BCR signaling	83, 135, 142, 194

KSHV	DNA	LANA	p53, pRb, c-Myc, GSK3β, MAPK2, FADD, core histones, Transcriptional activators-Brd2, Brd4, Sp1, AP-1, and CBP and transcriptional inhibitors HP1, Dnmt3 and mSin3	cell-cycle, cellular transcription, apoptosis, Notch, Wnt/β-catenin, ub-proteasome, chromatin remodeling	3–6, 50, 57, 67, 153

		vFLIP	TRAF2	Apoptosis, NFκB, JNK/AP1	85, 86, 148, 153

HBV	DNA	HBx	NFκB, p53, c-jun, c-fos, PKC, c-myc, SP1, HIF-1α	Cell-cycle, apoptosis, cellular transcription, NFκB Wnt/β-catenin, TGFβ, JAK/STAT, metastasis	40, 63, 68, 90, 195

MCPyV	DNA	LT	p53, pRb	Cell-cycle	17

HCV	RNA	NS3	p53, Arginine methyltransferase 1, PKA, H2B, H4	PKC, inflammation	158, 184, 196, 197

		NS5A	p53, Bax, IFN-induced dsRNA activated protein kinase (PKR), growth factor receptor-binding protein 2 (Grb2), PI3K p85 subunit, TRADD, CDK1, TRAF2, TBP	Cell-cycle, apoptosis, Ras-Erk MAPK pathway, PI3K, NFκB	13, 41, 198, 199

HTLV-1	RNA	Tax	Cyclic AMP, p300/CBP, MAD-1, MAD-2, cyclin D1, Chk1 and 2	Cell-cycle, apoptosis, cellular transcription, NFκB, PI3K/AKT, chromatin remodeling	15, 186, 200, 201

Most potent and studied viral oncoproteins.