Table 1.

Inclusion and exclusion criteria for the PROPEL trial.

Inclusion Criteria

• Age 20.0 – 75.0 years

• BMI 30.0 – 50.0 kg/m2

• Able to provide written informed consent

• Willing to change diet, physical activity and weight

• Patient of a participating clinic

• Able to participate in scheduled sessions

Exclusion Criteria

• Currently participating in a weight loss program

• Current use of weight loss medication or recent weight loss (>10 lbs in last six months)

• Plans to move from the area within 2 years

• Given birth within the past year, is currently pregnant or plans to become pregnant within 2 years

• Past bariatric surgery or plans for bariatric surgery within 2 years

• Current major depression

• History of suicidal behavior or diagnosed eating disorder (bulimia, anorexia)

• Hospitalization for mental disorder or substance abuse in the previous year

• Active cancer (except prostate, skin and thyroid if approved by physician)

• Serious arrhythmias or cardiomyopathy

• Severe congestive heart failure

• Stroke or heart attack in previous six months

• Chronic Inflammatory conditions, including but not limited to severe arthritis, lupus, or inflammatory bowel disease(i.e. Crohn’s disease or ulcerative colitis)

• Disease that is life threatening or that can interfere with or be aggravated by exercise or weight loss

• Discretion of primary care physician or principal investigator