Table 3. CSF, peripheral tissue and blood 125I levels 60 min following a single, one-time 125I-labled DNSP-11 dose.
125I signal was present in CSF, the thyroid gland, urine and blood samples as analyzed by gamma counter (Perkin-Elmer Cobra II Gamma Counter: Packard; preset energy range 15 to 74 KeV, 1 min runtime). Blood samples were taken from the saphenous vein in 15 min intervals following the start of the first intranasal dose (t=0). Data are presented as total 125I signal (CPM) and normalized 125I signal (CPM/mg). NHPs treated with vehicle only were found to have CPM values lower than background levels ≤ 50 cpm (data not shown).
| Samples | CPM (Counts Per Min) | Normalized CPM/mg |
|---|---|---|
| CNS | ||
| CSF | 2530 | 25 |
| Peripheral Samples | ||
| Thyroid Gland | 8181000 | 15480 |
| Urine | 1984500 | 19845 |
| Blood Samples | ||
| 15 min | 77850 | 779 |
| 30 min | 89160 | 892 |
| 45 min | 96970 | 970 |
| 60 min | 99700 | 997 |