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DREF as a function of the dose rate. Different exposure scenarios at different dose-rate levels are shown in the circles. DREF, dose-rate effectiveness factor; HDR-BT, high dose-rate brachytherapy; IMRT, intensity modulated radiotherapy; IORT, intraoperatory radiotherapy; LDR-BT, low dose-rate brachytherapy; MRT, microbeam radiotherapy; SBRT-FFF, stereotactic body radiotherapy flattening filter free; SRS, stereotactic radiosurgery.
