Table 1. Eye and disease characteristics.
Numbers shown are median (min, max) for continuous variables and N (%) for categorical variables.
| Overall (N = 436) | Era 1 (N = 166) | Era 2 (N = 270) | p-value | |
|---|---|---|---|---|
| Age at first visit (months) | 13.4 (0.1, 195.1) | 11.1 (0.3, 195.1) | 14.8 (0.1, 122) | 0.92 |
| Age at last treatment (months) | 16.8 (3.8, 196.9) | 15.9 (3.8, 196.9) | 17.8 (5.3, 124.5) | 0.462 |
| Weight (kg) at first OACa | 10 (4.5, 71) | 10 (4.5, 71) | 10.5 (5.4, 35.9) | 0.112 |
| Gender | 0.123 | |||
| Female | 219 (50.2) | 92 (55.4) | 127 (47) | |
| Male | 217 (49.8) | 74 (44.6) | 143 (53) | |
| Family history | 0.256 | |||
| No | 387 (88.8) | 143 (86.1) | 244 (90.4) | |
| Yes | 49 (11.2) | 23 (13.9) | 26 (9.6) | |
| Laterality | < .001 | |||
| Bilateral | 271 (62.2) | 114 (68.7) | 157 (58.1) | |
| Unilateral | 165 (37.8) | 52 (31.3) | 113 (41.9) | |
| Side | 0.781 | |||
| Left | 215 (49.3) | 83 (50) | 132 (48.9) | |
| Right | 221 (50.7) | 83 (50) | 138 (51.1) | |
| REb class | 0.507 | |||
| 1 | 11 (2.5) | 6 (3.6) | 5 (1.9) | |
| 2 | 24 (5.5) | 13 (7.8) | 11 (4.1) | |
| 3 | 44 (10.1) | 14 (8.4) | 30 (11.1) | |
| 4 | 27 (6.2) | 12 (7.2) | 15 (5.6) | |
| 5 | 279 (64) | 104 (62.7) | 175 (64.8) | |
| NA | 51 (11.7) | 17 (10.2) | 34 (12.6) | |
| ICRBc class | < .001 | |||
| A | 3 (0.7) | 0 (0) | 3 (1.1) | |
| B | 42 (9.6) | 20 (12) | 22 (8.1) | |
| C | 45 (10.3) | 18 (10.8) | 27 (10) | |
| D | 208 (47.7) | 85 (51.2) | 123 (45.6) | |
| E | 85 (19.5) | 28 (16.9) | 57 (21.1) | |
| NA | 53 (12.2) | 15 (9) | 38 (14.1) | |
| Vitreous seeds at first visit | 0.7 | |||
| No | 169 (38.8) | 57 (34.3) | 112 (41.5) | |
| Yes | 211 (48.4) | 71 (42.8) | 140 (51.9) | |
| NA | 56 (12.8) | 38 (22.9) | 18 (6.7) | |
| Subretinal seeds at first visit | 0.265 | |||
| No | 67 (15.4) | 28 (16.9) | 39 (14.4) | |
| Yes | 233 (53.4) | 72 (43.4) | 161 (59.6) | |
| NA | 136 (31.2) | 66 (39.8) | 70 (25.9) | |
| Germline mutation | 0.881 | |||
| Negative | 94 (21.6) | 31 (18.7) | 63 (23.3) | |
| Positive | 293 (67.2) | 119 (71.7) | 174 (64.4) | |
| NA | 49 (11.2) | 16 (9.6) | 33 (12.2) | |
| Treatment naive | < .001 | |||
| No | 208 (47.7) | 108 (65.1) | 100 (37) | |
| Yes | 228 (52.3) | 58 (34.9) | 170 (63) | |
| Intraoperative pressure hypertensive | 0.002 | |||
| No | 241 (55.3) | 90 (54.2) | 151 (55.9) | |
| Yes | 109 (25) | 13 (7.8) | 96 (35.6) | |
| NA | 86 (19.7) | 63 (38) | 23 (8.5) |
aOAC = ophthalmic artery chemosurgery
bRE = Reese-Ellsworth
cICRB = International Classification of Retinoblastoma