Table 3. Univariable Cox regression analysis for ocular survival.
| Era 1 | Era 2 | |||
|---|---|---|---|---|
| HRa (95% CIb) | p-value | HRa (95% CIb) | p-value | |
| Age at first visit (months) | 1.02 (1.00–1.03) | 0.005 | 1.01 (0.99–1.03) | 0.224 |
| Age at last treatment (months) | 1.02 (1.01–1.03) | 0.004 | 1.01 (0.99–1.03) | 0.427 |
| Weight (kg) at first OAC | 1.01 (0.98–1.04) | 0.514 | 1.05 (0.97–1.14) | 0.219 |
| Gender | 0.877 | 0.979 | ||
| Female | 1 | 1 | ||
| Male | 0.93 (0.37–2.35) | 1.01 (0.35–2.91) | ||
| Laterality | 0.064 | 0.461 | ||
| Bilateral | 1 | 1 | ||
| Unilateral | 2.38 (0.95–5.96) | 1.47 (0.53–4.10) | ||
| Side | 0.295 | 0.949 | ||
| Left | 1 | 1 | ||
| Right | 0.61 (0.24–1.54) | 0.97 (0.35–2.67) | ||
| REc class | 0.063 | 0.274 | ||
| 1 to 4 | 1 | 1 | ||
| 5 | 6.9 (0.90–52.64) | 3.16 (0.40–24.80) | ||
| Vitreous seeds at first visit | NA | 0.059 | ||
| No | 1 | |||
| Yes | NA | 4.25 (0.95–19.07) | ||
| Germline mutation | 0.01 | 0.956 | ||
| Negative | 1 | 1 | ||
| Positive | 0.29 (0.11–0.74) | 0.96 (0.27–3.44) | ||
| Treatment naive | 0.443 | 0.012 | ||
| No | 1 | 1 | ||
| Yes | 1.44 (0.56–3.69) | 6.04 (1.48–24.66) | ||
| Intraoperative pressure hypertensive | 0.762 | 0.171 | ||
| No | 1 | 1 | ||
| Yes | 0.73 (0.10–5.43) | 2.09 (0.73–6.02) | ||
| Maximum melphalan dose | 1.41 (1.09–1.84) | 0.009 | 0.98 (0.85–1.13) | 0.768 |
| Maximum topotecan dose | 1.24 (0.35–4.37) | 0.743 | 0.99 (0.92–1.07) | 0.86 |
| Maximum carboplatin dose | 1.01 (0.98–1.03) | 0.6 | 1.02 (0.98–1.06) | 0.282 |
| Cumulative melphalan dose | 1.07 (1.02–1.11) | 0.002 | 1.00 (0.93–1.07) | 0.953 |
| Cumulative topotecan dose | 1.16 (0.88–1.52) | 0.29 | 1.02 (0.97–1.08) | 0.376 |
| Cumulative carboplatin dose | 1.00 (0.99–1.01) | 0.943 | 1.00 (1–1.01) | 0.672 |
| OACd interval (weeks) | 1.00 (0.98–1.03) | 0.76 | 0.97 (0.90–1.06) | 0.523 |
| Greater than 3 infusions | 0.179 | 0.914 | ||
| No | 1 | 1 | ||
| Yes | 2.67 (0.64–11.22) | 0.93 (0.26–3.30) | ||
| Greater 50% OAd | 0.507 | 0.277 | ||
| No | 1 | 1 | ||
| Yes | 1.65 (0.38–7.21) | 0.56 (0.20–1.59) | ||
| First treatment OAd | 0.548 | 0.071 | ||
| No | 1 | 1 | ||
| Yes | 1.82 (0.26–12.81) | 0.38 (0.13–1.08) | ||
| Bridge | 0.79 | |||
| No | 1 | |||
| Yes | 1.19 (0.34–4.15) | |||
| International Bridge | NA | 0.135 | ||
| No | 1 | |||
| Yes | NA | 2.26 (0.78–6.60) | ||
aHR = hazard ratio
bCI = confidence interval
cRE = Reese-Ellsworth
dOAC = ophthalmic artery chemosurgery/ OA = ophthalmic artery