Figure 2.

Anticoagulant glycosaminoglycans-binding sequence for antithrombin and heparin cofactor II. A, The main heparin and heparan sulfate sequence for binding to antithrombin. B, The main dermatan sulfate sequence for binding to heparin cofactor II. C, Two heparin and heparan sulfate sequences for binding to heparin cofactor II. The sequences were predicted in silico, and their ability to neutralize those two glycosaminoglycans was confirmed in vitro.¹⁰ GlcA indicates glucuronic acid; and IdoA, iduronic acid.