Figure 4.

Representation of the key locations where circulatory glycosaminoglycans (GAG)-neutralizing proteins/molecules are derived. Numerous proteins normally bind to endothelial GAGs. They are displaced by injection of heparin. Several key neutralizing molecules are also found in the plasma. Activated platelets and neutrophils can also release such proteins through exocytosis of granular vesicles. Damaged cells expressing dermatan sulfate–containing proteoglycans also release GAG-neutralizing molecules.