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Group analysis of TGN-073 effect. Group treated with an experimental dose of TGN-073 (200 mg/kg) showed significantly higher I0 in the cortex compared with the saline-treated group, indicating higher turnover of [17O]H2O in the cortex. The group treated with a control dose of TGN-073 (20 mg/kg) did not show any significant effects, excluding potential nonspecific effects of TGN-073. *P=0.0066 (t-test). BG, basal ganglia; CSF, cerebrospinal fluid.
