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. 2018 Jan 17;91(1084):20170847. doi: 10.1259/bjr.20170847

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© 2018 The Authors. Published by the British Institute of Radiology

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Figure 2. — Effects of TMZ chemotherapy on physiological ¹⁸F-DOPA uptake. 155 PET/CT studies were divided into the following three groups according to chemotherapy treatment history: (i) no prior TMZ treatment (Group A, n = 48), (ii) TMZ treatment concluded >1 month before PET/CT (Group B, n = 50) and (iii) ongoing TMZ treatment (Group C, n = 57). Panel (a) shows significant differences of SUVbckgr between the three study groups; in particular, Group C has significantly lower SUVbckgr than Group B. Panel (b) shows variations of SUVbg between the three groups, which slightly missed the significance level. Panel (c) shows significant differences of SUVbckgr uptake among female patients (green colour scale); in particular, group C female patients have significantly higher SUVbckgr than group B female patients. Panel (d) shows fairly stable SUVbckgr in male patients (orange colour scale) grouped according to TMZ treatment history. In the figure, p-values refer to Turkey’s test for multiple comparisons and * indicates that differences between groups reached statistical significance (p < 0.05). ¹⁸F-DOPA, ¹⁸F–fluoro-l–phenylalanine; PET, positron emission tomography; SUV, standardized uptake value; TMZ, temozolomide.