Table 3. .

Comparison between conventional and immune-related response criteria

		WHO	IrRC	RECIST 1.0	RECIST 1.1	IrRECIST	iRECIST
Definition of target		No minimum lesion size; should be measurable in two dimensions	No minimum lesion size; should be measurable in two dimensions	>10 mm in long-axis	>10 mm in long-axis for non-nodal lesions and >15 mm in short-axis for lymph nodes	>10 mm in long-axis for non-nodal lesions and >15 mm in short-axis for lymph nodes	>10 mm in long-axis for non-nodal lesions and >15 mm in short-axis for lymph nodes
Max. no. of targets		N/A	15 (10 visceral + 5 cutaneous)	10	5	5	5
No. of targets per organ		N/A	5	5	2	2	2
Tumour burden		SPD	SPD	SLD	SOD (short-axis for lymph nodes)	SOD (short-axis for lymph nodes)	SOD (short-axis for lymph nodes)
New lesions	Number	N/A	15 lesions in total (10 visceral + 5 cutaneous), 5 per organ	N/A	N/A	5 lesions in total (2 per organ)	5 lesions in total (2 per organ)
Size	N/A	≥5 × 5 mm	N/A	N/A	≥10 mm in long-axis (15 mm short-axis for lymph nodes)	≥10 mm in long-axis (15 mm short-axis for lymph nodes)

irRC, immune-related response criteria; irRECIST, immune-related RECIST; Max, maximum; No, number; N/A, not applicable; RECIST, Response Valuation Criteria in Solid Tumours; SLD, sum of long-axis diameters; SOD, sum of diameters; SPD, sum of products of perpendicular diameters; WHO, World Health Organization.