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. Author manuscript; available in PMC: 2019 Apr 9.
Published in final edited form as: Cancer Cell. 2018 Apr 2;33(4):721–735.e8. doi: 10.1016/j.ccell.2018.03.010

Figure 7. Integrated Molecular Comparison of Somatic Alterations Across GIAC Molecular Subtypes.

Figure 7

(A–C) Alterations in select genes and pathways including RTK/RAS/PI3-K (A), TP53, cell cycle (B), and WNT/TGFβ (C). Deep deletions representing loss of more than half of the gene copies for the given ploidy of the tumor, blue; amplifications, red; missense mutations in the COSMIC repository, green; nonsense or frameshift mutations, black. Percentage of somatic alteration is indicated by numbers to the left of each gene box and divided by upper (U) and lower GI (L).