Figure 8.

Axial, sagittal and coronal slices of a patient with glioblastoma injected with fluorine-18 fluoroethyl-L-tyrosine, showing the reconstructed map of the k₃ microparameter obtained from indirect reconstruction (maximum a posteriori-expectation maximization using Green's one-step-late approach) (a), direct methods using distance weighting in the activity images (b) and Bowsher weighting with simultaneous regularization of activity images and kinetic parameters (c). Reproduced from Loeb et al¹⁷¹ with permission from the IEEE.