Table 5.
Summary of areas of no consensus. +modal answer agree; o, modal answer notnecessary; x, modal answer disagree;
Standardisation– No consensus | |
Acquisition | |
A minimum reconstructed pixel size at 1.5T and 3T | + |
A minimum of 3 averages per bb-value at 1.5T and 3T for routine clinical | + |
The gradient encoding scheme to be 3 orthogonal directions. | o |
The fat suppression technique to be STIR at 3T only | o |
The acquired slice thickness to be no less than 5 mm at 3T only | + |
A maximum axial FoV at 3T | o |
A minimum acquisition pixel size at 3T only | + |
Optimisation | |
No consensus for routine clinical imaging at 1.5T and 3T to | |
Perform repeatability and reproducibility scans on normal volunteers | o |
Perform optimisation of sequence on a sugared water test object at room temp | + |
RoutineQA and QC | |
No consensusfor routine clinical imaging at 1.5T and 3T to | |
Perform monthly tests | o |
The type of tests that should be done or how to do them | |
ADC linearity in the Z-axis | + |
Measure B0 distortion | o |
Measure the eddy current distortion | o |
ADC linearity in 3 different directions | + |
What test object should be used | |
Iced water phantom | + |
With known biologically relevant ADC values | + |
Minimallydiffusing medium (e.g. oil) | o |
No consensus for research trial imaging at 1.5T and 3T to | |
Performdaily or weekly tests | o |
The type of tests that should be done | |
ADC linearity in three directions | o |
AnalysisVisualisation & Reporting | |
No consensus was reached for basic ADC quantitation on whether | |
A base signal intensity noise level should be set prior to ADCcalculation | + |
To perform a bed station signal intensity normalisation over thewhole body prior to ADC calculation | x |
No consensus was reached for disease staging and response assessment on how | |
To define a ROI/VOI | |
Geometric | o |
Set threshold based on Max value | o |
Use another MR weighted image to free draw VOI/ROI (staging only) | o |
Whether whole body disease burden would be a useful measure | o |
Reporting the standard deviation for each VOI/ROI | + |
Specifying a percentage value of increase or decrease of tumour volume onsome ADC threshold to indicate positive or negative response respectively. | + |
ADC values should be reported alongside | |
Biopsy samples | o |
Blood serum markers | o |
Other modality images (response assessment only) | + |
Using arotating greyscale MIP of whole body ADC map similar to whole PET scan | o |
The need for image registration for longitudinal reporting | + |