Figure 2.

Force threshold (g) difference (mean ± SEM) between the left (injected paw), and right (control paw). Afternoon baselines (B1 and B3) were averaged, and evening baselines (B2 and B4) were averaged. (A) Tolerance at 3 and 6 h was decreased compared with averaged afternoon and evening baseline measurements. (B) Tolerance did not differ significantly compared with averaged afternoon and evening baseline measurements for any dose of robenacoxib. (C) Mice treated with 10 mg/kg robenacoxib showed significantly increased tolerance at 3 and 6 h when compared with saline-treated animals. (D) Animals given 32 mg/kg robenacoxib showed significantly increased tolerance at 3 h when compared with saline-treated animals. #, P < 0.05 compared with baseline; *, P < 0.05 compared with saline at a given time point.