Figure 3.

Sagittal paw width difference (mm; mean ± SEM) between the left paw before and after injection of carrageenan (30 μL) for all doses and control. Change over time within a dose group was significantly different from baseline in the (A) saline-treated mice at 48 h (mean difference, 0.48 mm); (B) the 3.2 mg/kg robenacoxib group at 6 h (shows increased swelling compared with saline); (C) 10 mg/kg robenacoxib at 48 h (mean difference, 0.33 mm; with a 0.15-mm difference from the saline mean difference in the direction of increased swelling); (D) 32 mg/kg robenacoxib at 24 and 48 h (mean difference, 0.54 mm; with a 0.06-mm difference from the saline mean difference in the direction of decreased swelling, and most similar to saline); (E) 100 mg/kg robenacoxib at all time points except 6 h, and overall showed less swelling over time. #, P < 0.05 relative to baseline.