. 2018 Mar 19;9(36):24221–24236. doi: 10.18632/oncotarget.24823

Table 2. Effects of 8-prenylgenistein on trabecular bone parameters measured by micro-CT at the proximal metaphysis of tibia (A) and the distal metaphysis of femur (B) in ovariectomized mice.

A
Parameters\Group	Sham	OVX	Gen	8PG-L	8PG-H
BMD/TV (mg HA/ccm)	105 ± 7	59 ± 3^##	67 ± 9	74 ± 6	85 ± 6^*
Conn.D (1/mm³)	360 ± 55	136 ± 31^#	211 ± 32	197 ± 15	202 ± 18
BV/TV (%)	87.9 ± 5.9	50.7 ± 5.7^##	67.7 ± 12.8	71.3 ± 11.3	77.0 ± 13.5
DA	1.35 ± 0.04	1.81 ± 0.03^#	1.60 ± 0.08	1.34 ± 0.05^*	1.34 ± 0.03^*
Tb.N (1/mm)	2.7 ± 0.1	1.6 ± 0.1^###	1.9 ± 0.2	1.9 ± 0.2	1.9 ± 0.2
Tb.Sp μm)	337 ± 17	591 ± 48^##	498 ± 72	509 ± 55	439 ± 43^*
Tb.Th (μm)	33.3 ± 1.0	30.8 ± 2.2	33.8 ± 4.9	36.7 ± 2.3	39.8 ± 1.4^**
B
Parameters\Group	Sham	OVX	Gen	8PG-L	8PG-H
BMD/TV (mg HA/ccm)	149 ± 15	97 ± 7^#	137 ± 7^*	141 ± 13^*	151 ± 8^**
Conn.D (1/mm³)	266 ± 40	135 ± 26^#	210 ± 40	179 ± 19	192 ± 22
BV/TV (%)	16.6 ± 2.1	10.1 ± 0.6^#	16.8 ± 0.9^**	15.9 ± 1.9^*	19.7 ± 1.2^**
DA	1.27 ± 0.02	1.34 ± 0.10	1.34 ± 0.05	1.25 ± 0.03	1.30 ± 0.07
Tb.N (1/mm)	3.5 ± 0.2	2.3 ± 0.1^##	3.0 ± 0.2^*	3.1 ± 0.2^*	3.2 ± 0.2^*
Tb.Sp (μm)	243 ± 17	385 ± 13^###	273 ± 17^**	295 ± 27^*	257 ± 24^**
Tb.Th (μm)	52.3 ± 2.2	43.5 ± 2.9^#	54.9 ± 3.8	59.6 ± 3.7^*	62.4 ± 0.8^**

Values were expressed as means ± SEM, n = 8 in each group. ^#P < 0.05, ^##P < 0.01, ^###P < 0.001, vs. Sham; ^*P < 0.05, ^**P < 0.01, vs. OVX. BMD/TV, bone mineral density over total volume; Conn.D, connectivity density; BV/TV, bone volume over total volume; DA, degree of anisotropy; Tb.N, trabecular bone number; Tb.Sp, trabecular bone separation; Tb.Th, trabecular bone thickness.