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. 2018 Mar 19;9(36):24221–24236. doi: 10.18632/oncotarget.24823

Table 3. Differential actions of genistein and 8-prenylgenistein on bone and uterus in ovariectomized mice and human endometrial Ishikawa cell.

Genistein 8-prenylgenistein
Biochemical markers
Serum Ca
Urinary Ca
Bone resorption marker
(serum OPN)		 No change
No change
No change		 Inline graphic
Inline graphic
Inline graphic
Bone properties
Tibial head
BMD
Tb.Th
DA
Tb.Sp		 No change
No change
No change
No change		 Inline graphic
Inline graphic
Inline graphic
Inline graphic
Femoral end
BMD
BV/TV
Tb.N
Tb.Th
Tb.Sp		 Inline graphic
Inline graphic
Inline graphic
No change
Inline graphic 		Inline graphic
Inline graphic
Inline graphic
Inline graphic
Inline graphic
Uterus response
Uterus index
PR
ER-α
C3		 Inline graphic
Inline graphic
Inline graphic
No change		 No change
No change
Inline graphic
Ishikawa cell
ER-α
PCNA
C3		 Inline graphic
No change
No change
No change
Binding affinities (RBA)
ER-α
ER-β		 0.99%
58.1%		 4.31%
99.6%

BMD, bone mineral density; BV/TV, bone volume over total volume; C3, complement component 3; Ca, calcium; DA, degree of anisotropy; ER-α, estrogen receptor alpha; ER-β, estrogen receptor beta; OPN, osteopontin; PCNA, proliferating cell nuclear antigen; PR, progesterone receptor; RBA, relative binding affinity; Tb.N, trabecular bone number; Tb.Sp, trabecular bone separation; Tb.Th, trabecular bone thickness.