Table 3A. Results of the subgroup analyses performed to identify potential sources of heterogeneity.
| Variables | No. of data | Sensitivity | Specificity | PLR | NLR | DOR | AUC |
|---|---|---|---|---|---|---|---|
| Overall | 18 | 0.735 (0.713-0.757) |
0.918 (0.900-0.934) |
8.295 (5.037-13.659) |
0.300 (0.231-0.391) |
30.783 (16.965-55.856) |
0.8818 |
| Measuring object ALU247/ALU115 | 3 | 0.747 (0.679-0.808) |
0.939 (0.894-0.969) |
9.398 (3.413-25.875) |
0.277 (0.149-0.516) |
37.767 (9.912-143.90) |
0.9275 |
| ALU115&CFDlevels | 13 | 0.717 (0.691-0.742) |
0.917 (0.895-0.935) |
8.235 (4.399-15.414) |
0.334 (0.246-0.454) |
27.825 (13.371-57.903) |
0.8652 |
| Country China | 6 | 0.705 (0.672-0.736) |
0.977 (0.960-0.987) |
24.618 (13.119-46.195) |
0.312 (0.202-0.480) |
89.386 (38.281-208.71) |
0.9293 |
| Italy | 5 | 0.818 (0.782-0.850) |
0.837 (0.785-0.881) |
5.200 (2.828-9.564) |
0.212 (0.155-0.290) |
25.453 (11.234-57.669) |
0.8688 |
| Other countries | 7 | 0.656 (0.592-0.715) |
0.866 (0.816-0.906) |
4.269 (2.603-6.999) |
0.416 (0.280-0.618) |
12.084 (5.547-26.324) |
0.8667 |
| Sample Plasma | 5 | 0.707 (0.666-0.745) |
0.900 (0.854-0.935) |
6.868 (3.927-12.013) |
0.214 (0.099-0.460) |
31.501 (12.377-80.176) |
0.9365 |
| serum | 13 | 0.750 (0.723-0.776) |
0.924 (0.903-0.941) |
8.858 (4.435-17.691) |
0.324 (0.244-0.431) |
29.789 (13.668-64.923) |
0.8581 |
| sample size ≥ 100 | 7 | 0.739 (0.712-0.765) |
0.939 (0.914-0.958) |
11.397 (5.602-23.186) |
0.273 (0.184-0.405) |
43.554 (20.432-92.843) |
0.8932 |
| < 100 | 11 | 0.726 (0.684-0.766) |
0.898 (0.870-0.923) |
6.390 (3.480-11.731) |
0.319 (0.218-0.467) |
23.910 (10.374-55.107) |
0.8772 |