Figure 6. Effect of HX-1171 on pancreatic beta cells in the STZ-induced diabetic mouse model.

(A) Hematoxylin and eosin (H&E)-stained pancreas sections in untreated, STZ-only treated (200 mg/kg, i.p.), HX-1171-co-treated (125 mg/kg, p.o.), and HX-1171-post-treated (p.o. one day after STZ injection) mice. (B) Insulin-, GCLM-, and caspase-3-expressing cells in the pancreas were analyzed by immunohistochemistry. All images (Figure 6A and 6B) are shown at 400× magnification. Scale bar = 50 μm.