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. 2018 Mar 9;37(21):2873–2889. doi: 10.1038/s41388-018-0183-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — High exosomal miR-23a promoted HUVEC proliferation, migration, and tube formation. a Forty-eight hours after treatment with exosomes isolated from CM of transfected CNE-2 cells, miR-23a levels of HUVECs were measured by qRT-PCR. One-way ANOVA. b Viabilities of HUVECs treated with various exosomes were measured by the CCK8 assay. Two-way ANOVA. c, d Cell-cycle analysis was performed 48 h after treatment with exosomes. The graph summarizes the results of three independent experiments. One-way ANOVA. e, f Wound-healing assay showed the migration of HUVECs treated with various exosomes. Two-way ANOVA. g, h Transwell migration assays were performed to measure cell migration. One-way ANOVA. i Tube formation assays using HUVECs supplemented with exosomes were conducted using Matrigel. j, k Western blot of p-ERK in HUVEC incubation with exosomes. β-actin was used as a loading control. The results were analyzed with ImageJ software. One-way ANOVA