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. 2018 May 23;4:11. doi: 10.1038/s41526-018-0045-0

Fig. 5.

Fig. 5

Hypothetical model of regulation of myogenesis. Differentiation signals regulate DNA methylation machinery, and especially, the Myod1 gene in myoblast cells, resulting in sequential activation of target genes and consecutive myogenic differentiation. Simulated microgravity attenuated this myogenesis by controlling DNA methylation status of Myod1. This signal pathway was also controlled using DNA methylation inhibitor, 5-AzaC, treatment