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Two possible gating mechanisms of Piezo1. Our study reveals Yoda1 sensitivity of Piezo1 requires the presence of only one Yoda1-sensitive subunit per trimer. This result is consistent with a concerted gating mechanism (a) where all subunits cooperatively gate the pore (blue: resting subunits; magenta: activated subunits). This result is also consistent with a sequential mechanism (b) where the pore fully opens if only one subunit is activated
