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. 2018 May 23;8:8072. doi: 10.1038/s41598-018-26156-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Adenosine-to-Inosine (ADARs) modifications in mature microRNAs. (A) ADARs occurs all along the sequence of microRNAs, including part of the seed sequence. Of note, they barely occur in the microRNA extremes. (B) Counts of all microRNAs with detected ADARs. There is a slight but statistically significant drop in the number of microRNAs with detected ADARS in CM compared to PSC. (C) Expression level of the ADAR modifications. On the left panel, overall expression (in CPM) of ADARs is compared against microRNA expression. There is no significant changes along differentiation. On the right panel, ADAR expression is depicted as percentage of expression of the mature microRNA. Overall, ADARs are a low percentage of mature forms, except for a few cases.