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. 2018 May 23;8:8072. doi: 10.1038/s41598-018-26156-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of microRNA expression with external data bases. (A) Scatter plot of microRNA expression in PSC (internal database, y axis) and an external database (x axis). (B) Heatmap depicts expression level of microRNAs from 6 cell lines including CM, Mesenchymal progenitor cells (MPC), Human lung fibroblasts (HLF), Forebrain Neural progenitor cells (F_NPC), Midbrain Neural progenitor cells (M_NPC) and Hindbrain Neural progenitor cells (H_NPC) with their respective replicates. (C) Differential expression of microRNAs between CM and the non-cardiac cell lines (external data) are depicted in the Volcano plots. Blue lines delineate the cutoff for microRNAs significantly upregulated (red) and downregulated (green) with a log2 FC ≥ 3 and p ≤ 0.01. Names show the most extreme microRNAs.