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. 2018 May 23;8:8047. doi: 10.1038/s41598-018-26446-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Phylogenetic analysis of isolated HDV genotypes. (A) A phylogenetic tree was constructed based on the alignment of 235 bp of 57 nucleotide sequences isolated from HDV/HBV co-infected patients. 39 full-length HDV genomes through HDV1-8 retrieved from NCBI database along with GenBank accession numbers were included for the analysis. A neighbor-joining tree was constructed with a bootstrap of 1000 replicates. The bar at the base of the tree indicates the scale for nucleotide substitutions per position. (B) The phylogenetic tree was constructed only for HDV genotype 1 and 2 sequences and involves 82 nucleotide sequences (25 references of full-length HDV genome retrieved from NCBI database, 52 strains of HDV genotype 1 (denoted as ♦) and 5 HDV genotype 2 (denoted as •) from HBV/HDV coinfected patients in our study group.