Fig. 2. Expression of laminin-332, laminin α5, laminin β2 and laminin γ3 in developing human retina.

a) Laminin-332 (green) is expressed in BrM and throughout the retina in all developmental stages. b) Laminin α5 (green) was found in BrM and the ILM throughout development and additionally in ONBZ, INBZ and IPL at 12 PCW. c) Laminin β2 (green) was observed in BrM developmental stages as well as in INBZ at 16 PCW. d) Laminin γ3 (green) is expressed throughout the retina during development. Nuclei are counterstained with Hoechst (blue). BrM Bruch’s membrane, RPE retinal pigment epithelium, ONBZ outer neuroblastic zone, ONL outer nuclear layer, OPL outer plexiform layer, INBZ inner neuroblastic zone, INL inner nuclear layer, IPL inner plexiform layer, GCL ganglion cell layer, ILM inner limiting membrane, Hoe Hoechst, Lam laminin, PCW post conceptual week. Scale bars, 20 μm