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. 2018 May 23;9:2040. doi: 10.1038/s41467-018-04456-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Effect of Tet2/Tet3 deficiency on liver function. a Liver to body weight ratio (±s.d.) in 15-week-old WT and DKO mice induced at 1 day or 3 weeks. b WT and DKO (1 day) liver. c E-cadherin staining of sections from 15-week-old WT and DKO mice induced at 1 week. d Box plot of hepatocyte cell size (μ²) based on E-cadherin staining in 15-week-old WT and DKO male (M) and female (F) mice induced at 1 day or 3 weeks. e Serum glucose or f cholesterol, HDL, and triglyceride levels (±s.d.) of 15-week-old WT and DKO mice. Results are also shown for DKO males castrated at 3 weeks (M^Cast)