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. 2018 Apr 27;9(6):613. doi: 10.1038/s41419-018-0573-2

Fig. 1. In vivo assessment of TG2 inhibition on AngII-induced cardiac fibrosis.

Fig. 1

AngII 1.1 mg/kg/day in 50% DMSO in PBS pH 7.4 was used to induce cardiac fibrosis for 2 weeks with or without TG2 inhibitor (25 mg/kg/day) via a subcutaneously implanted mini-pump (Alzet1002). a Representative images of heart sections from the inhibitor and non-inhibitor-treated animals showing collagen staining using Picro-Sirius red. Bar = 100 µm. b Averaged data of Picro-Sirius red/collagen staining in heart sections from control and TG2 inhibitor 1–155 treated animals. c TG2-mediated ε(γ-glutamyl)lysine crosslink (XL) formation in the AngII and AngII+ 1–155 treated animals. d–f Systolic blood pressure (SBP) (d), heart rate (e), and heart weight (HW, wet weight, mg) against body weight (BW, g). f were obtained after 2 weeks of treatment with 1–155. Data are means ± SE. n = 5/4. *p < 0.05