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. 2018 Apr 27;9(6):613. doi: 10.1038/s41419-018-0573-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Representative western blot (n = 3) showing p-Smad2/3 activation, VE-cadherin and FN expression, and FN deposition into the matrix in HUVECs treated with TGFβ1 in the presence or absence of t TG2 inhibitor 1–155. b The V2a AngioKit co-culture model was used as described in the 'Materials and methods' to study the effects of TGFβ1 on endothelial tubule formation. Representative images show the inhibitory effects of TGFβ1 on tubule formation at the concentration shown over 12 days. c Representative western blot (n = 3) showing Smad2/3 activation in mouse TG2^+/+ and TG2^−/− microvascular ECs following TGFβ1 treatment for 72 h at the concentrations shown. d Representative western blot (n = 3) showing the effects of thioredoxin treatment on HUVECs showing Smad2/3 activation, expression of FN, VE-Cadherin and TG2