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. 2018 May 23;8:8071. doi: 10.1038/s41598-018-26369-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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High-density association mapping at NELFCD and CTSZ loci. The top panel shows estimates of pairwise r² for 33 SNPs used in the high-density association mapping at NELFCD and CTSZ loci (chr 20, nucleotide positions 57514197–57715109, hg19) using a total of 1,375 samples including 173 jaundice-stage and 1,202 early-stage PBC patients. The bottom panel shows P values (●) and OR (○) based on chi-square tests for the allelic model. Red diamond () and red triangle () show rs13720 and rs163800, respectively.

Inline graphic — High-density association mapping at NELFCD and CTSZ loci. The top panel shows estimates of pairwise r² for 33 SNPs used in the high-density association mapping at NELFCD and CTSZ loci (chr 20, nucleotide positions 57514197–57715109, hg19) using a total of 1,375 samples including 173 jaundice-stage and 1,202 early-stage PBC patients. The bottom panel shows P values (●) and OR (○) based on chi-square tests for the allelic model. Red diamond () and red triangle () show rs13720 and rs163800, respectively.