Table 3.
Top 10 pathway enrichment hits derived from differentially expressed transcripts in CD141+ mDCs in malignant tonsil compared to CD141+ mDCs in benign tonsils.
| Enrichment hit | FDR | Ratio | Associated transcripts |
|---|---|---|---|
| CD141 + mDCs malignant tonsil > CD141 + mDCs benign tonsils | |||
| Immune response_IFN-alpha/beta signaling via JAK/STAT | 6,856E-04 | 5/64 | IFI27, IP10, IRF1, GBP1, PML |
| Immune response_T regulatory cell-mediated modulation of antigen-presenting cell functions* | 1,659E-01 | 3/66 | IRF1, SLC7A5, LAG3 |
| Cell cycle_Role of 14-3-3 proteins in cell cycle regulation* | 1,717E-01 | 2/22 | CDC25B, 14-3-3 sigma |
| NETosis in SLE* | 1,987E-01 | 2/31 | Histone H2, Histone H2A |
| Cell cycle_Spindle assembly and chromosome separation* | 1,987E-01 | 2/33 | TPX2, Aurora-B |
| Cell cycle_The metaphase checkpoint* | 1,987E-01 | 2/36 | SPBC24, Aurora-B |
| Apoptosis and survival_NGF activation of NF-kB* | 1,987E-01 | 2/40 | Bcl-XL, TGM2 |
| Apoptosis and survival_BAD phosphorylation* | 1,987E-01 | 2/42 | Bcl-XL, 14-3-3 |
| Immune response_CRTH2 signaling in Th2 cells* | 1,987E-01 | 2/44 | Bcl-XL, 14-3-3 |
| Development_PIP3 signaling in cardiac myocytes* | 1,987E-01 | 2/47 | Bcl-XL, 14-3-3 |
| CD141 + mDCs malignant tonsil < CD141 + mDCs benign tonsils | |||
| Immune response_IL-11 signaling pathway via MEK/ERK and PI3K/AKT cascades | 2,205E-04 | 9/67 | I-kB, SFK, Osteocalcin, Fyn, gp130, NFKBIA, c-Jun, Caspase-9, c-Fos |
| Immune response_IL-6-induced acute-phase response in hepatocytes | 2,205E-04 | 7/36 | Heme oxygenase 1, c-Jun/c-Fos, gp130, IL-6 receptor, c-Jun, IL6RA, c-Fos |
| Reproduction_Gonadotropin-releasing hormone (GnRH) signaling | 2,205E-04 | 9/72 | c-Jun/c-Fos, AP-1, PER1, Adenylate cyclase, c-Jun, MKP-1, c-Fos, G-protein alpha-q/11, PLC-beta |
| Immune response_IL-6 signaling pathway via JAK/STAT | 2,205E-04 | 9/72 | sIL6-RA, Osteocalcin, c-Jun/c-Fos, gp130, AP-1, IL-6 receptor, c-Jun, IL6RA, c-Fos |
| Aberrant production of IL-2 and IL-17 in SLE T cells | 3,228E-04 | 8/58 | Syk, I-kB, Fc epsilon RI gamma, c-Jun/c-Fos, MHC class II, AP-1, CD4, c-Fos |
| Immune response_M-CSF-receptor signaling pathway | 4,003E-04 | 9/81 | Syk, GAB3, c-Jun/c-Fos, GLUT1, Fyn, AP-1, PLD2, c-Jun, c-Fos |
| Immune response_MIF-induced cell adhesion, migration and angiogenesis | 5,059E-04 | 7/46 | CD44, c-Jun/c-Fos, AP-1, CXCR4, c-Jun, MKP-1, c-Fos |
| Immune response_Histamine H1 receptor signaling in immune response | 5,135E-04 | 7/47 | I-kB, c-Jun/c-Fos, NFKBIA, c-Jun, c-Fos, G-protein alpha-q/11, PLC-beta |
| Immune response_IL-22 signaling pathway | 1,089E-03 | 6/36 | IL10RB, c-Jun/c-Fos, MHC class II, c-Jun, CD4, c-Fos |
| Development_Angiotensin signaling via PYK2 | 3,207E-03 | 6/44 | c-Jun/c-Fos, AP-1, c-Jun, c-Fos, G-protein alpha-q/11, PLC-beta |