Fig. 2.

Enrichment analysis and functional classification of proteins. a The closest point of the total protein quantity range (100 ng) was chosen to compare the MS relative abundances after normalisation. b Among the 366 proteins identified with at least 2 peptides in the rosettes sample, 312 proteins were enriched with a rosette/total proteome abundance ratio ≥ 1.5 (log ratio ≥ 0.6 in red). c Manual sorting of the proteins according to their characterization in the literature. Among the 312 enriched proteins, 42% (95 proteins) were associated to cancer invasion including 37 proteins already described in the invadosomes. d The bart chart represents the classification of the 312 enriched proteins according to the GO categories (“Protein class” classification from the PANTHER database). Among the 70 nucleic acid proteins, 60 proteins were sub-classified as RNA-binding proteins whose functional assignments distribution is represented into the pie chart