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. 2018 May 23;9(6):611. doi: 10.1038/s41419-018-0620-z

Fig. 3. Metformin-mediated osteosarcoma cell invasion and autophagy by negatively regulating miR-570-3p expression in osteosarcoma.

Fig. 3

a Heat map of genes exhibiting significant induction (red) at 24 h after metformin treatment in 143B cells (expressed as a ratio to 143B cells treated with DMSO; fold change 42, P-value 0.05, data are log2 transformed). b The expression levels of miR-570-3p were examined in six osteosarcoma cell lines. c qRT-PCR demonstrated that miR-570-3p expression was markedly enhanced after metformin treatment in a dose- and time-dependent manner. d The knockdown of miR-570-3p reduced the metformin effects on invasion and autophagy in osteosarcoma cells. Data represent the mean ± S.D. (n = 3) in (b) and (c). **P < 0.01 by Student’s t-test