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Bioluminescence imaging and histology of immunocompromised mice following orthotopic injection of c-Fos transformed murine OS cells showing marked primary tumour formation and lung metastasis. Control OS cells (control shRNA) (A) showing lung metastases are inhibited by expressing an shRNA directed against Fgfr1 (B). H&E stained sections of control (C) and Fgfr1 knockdown (D) lungs show reduced lung nodules. Images generated by C. Zandueta/F. Lecanda (CIMA, Pamplona, Spain) [37].
