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5448-infected TEpi cells show reduced levels of IL-8 detected. IL-8 produced by TEpi cells intracellularly infected with GAS strains 5448 and JRS4, as measured by ELISA. Data are plotted as the mean ± s.e.m. and are combined from three independent experiments performed in triplicate and analyzed by two-way ANOVA with Tukey's post-test. Significance is shown relative to mock at each timepoint. **P < 0.01; ***P < 0.001; ****P < 0.0001.
