Table 3.
Minimum Inhibitory concentrations (MICs), 23S rRNA gene mutations, ribosomal protein substitutions and cmeRABC locus alleles in 10 erythromycin-resistant C. jejuni isolates.
| Strain | Ery MIC (mg/L) | Mutation in 23S rRNA gene | ermB | Ribosomal protein polymorphisms | cmeR | RAIVS | |
|---|---|---|---|---|---|---|---|
| L4 mutation | L22 mutation | ||||||
| 810 | >256 | A2075G | – | A196V | V65I, G74A, T109S, A111E, A114T | 3 | 3 |
| 1062 | >256 | WT | – | A196V | V65I, G74A, T109S, A111E, A114T | WT | WT |
| 1396 | >256 | WT | – | 0 | G74A, A103V, T109A, A111E, A114T | 4 | 4 |
| 656 | 12 | WT | – | 0 | Q24R, V65I, G74A, T109A, A111E, A114T | 2 | 2 |
| 713 | 128 | WT | – | A196V | V65I, G74A, T109S, A111E, A114T | NT | NT |
| 783 | 32 | WT | – | A196V | V65I, G74A, T109S, A111E, A114T | 3 | 3 |
| 856 | 6 | WT | – | M192I, V121A | G74A, T109A, A111E, A114T | 2 | 2 |
| 872 | >256 | WT | – | 0 | V65I, G74A, T109S, A111E, A114T | WT | WT |
| 1680 | >256 | WT | – | M192I, V121A, T177S | V65I, G74A, T109A A111E, A114T | 2 | 2 |
| 2136 | 12 | WT | – | A196V | V65I, G74A, T109S, A111E, A114T | 5 | 4 |
WT, wild type (with respect to C. jejuni strain NCTC 11168); NT, not tested; RAIVS, cmeRA intervening sequence. For cme locus alleles, see also Figure S1.