Table 2.
Cerebral microbleeds and cognitive decline
| Number of participants |
LDST | WFT | Stroop reading | Stroop naming | Stroop interference | WLT immediate | WLT delayed | WLT recognition | Purdue Pegboard | |
|---|---|---|---|---|---|---|---|---|---|---|
|
|
||||||||||
| No microbleeds | 2780 | Reference | Reference | Reference | Reference | Reference | Reference | Reference | Reference | Reference |
| Microbleed, any | 477 | −0.05 (−0.12;0.02) | 0.02 (−0.06;0.11) | 0.01 (−0.08;010) | −0.03 (−0.10;0.04) | −0.07 (−0.14;0.00) | −0.01 (−0.09;0.08) | 0.04 (−0.07;1.14) | 0.03 (−0.07;0.14) | −0.03 (−0.13;0.06) |
| Single | 326 | −0.02 (−0.09;0.06) | 0.04 (−0.06;0.14) | 0.06 (−0.04;0.17) | −0.02 (−0.10;0.06) | −0.07 (−0.15;0.01) | 0.0004 (−0.10;0.10) | 0.08 (−0.04;0.20) | 0.04 (−0.10;0.17) | −0.01 (−0.12;0.11) |
| 2–4 | 107 | −0.05 (−0.18;0.09) | 0.09 (−0.08;0.26) | 0.07 (−0.11;0.25) | 0.05 (−0.08;0.19) | −0.02 (−0.16;0.11) | 0.08 (−0.09;0.25) | −0.01 (−0.21;0.20) | −0.09 (−0.31;0.14) | −0.01 (−0.20;0.18) |
| >4 | 44 | −0.32 (−0.53;−0.10) | −0.35 (−0.62;−0.08) | −0.60 (−0.89;−0.31) | −0.35 (−0.57;−0.13) | −0.20 (−0.42;0.02) | −0.31 (−0.58;−0.03) | −0.20 (−0.54;0.14) | −0.13 (−0.49;0.24) | −0.33 (−0.64;−0.03) |
|
|
||||||||||
| Lobar* | 354 | −0.05 (−0.13;0.03) | 0.001 (−0.10;0.10) | −0.01 (−0.11;0.10) | −0.03 (−0.11;0.05) | −0.06 (−0.13;0.02) | −0.01 (−0.11;0.09) | 0.04 (−0.08;0.17) | 0.06 (−0.06;0.19) | −0.05 (−0.16;0.06) |
| Single | 253 | −0.02 (−0.11;0.07) | 0.03 (−0.08;0.14) | 0.05 (−0.07;0.17) | −0.05 (−0.14;0.04) | −0.08 (−0.17;0.01) | 0.02 (−0.10;0.13) | 0.10 (−0.04;0.24) | 0.09 (−0.06;0.24) | −0.03 (−0.16;0.09) |
| 2–4 | 78 | −0.07 (−0.23;0.08) | 0.05 (−0.15;0.24) | 0.03 (−0.18;0.23) | 0.07 (−0.09;0.23) | 0.04 (−0.12;0.20) | −0.01 (−0.21;0.19) | −0.06 (−0.30;0.19) | −0.16 (−0.43;0.11) | −0.11 (−0.32;0.11) |
| >4 | 23 | −0.33 (−0.62;−0.03) | −0.52 (−0.88;−0.15) | −0.87 (−1.26;−0.47) | −0.35 (−0.65;−0.05) | −0.22 (−0.52;0.08) | −0.38 (−0.76;−0.002) | −0.34 (−0.81;0.15) | −0.14 (−0.64;0.37) | −0.09 (−0.50;0.33) |
|
|
||||||||||
| Deep or infratentorial± | 123 | −0.05 (−0.17;0.08) | 0.08 (−0.08;0.23) | 0.08 (−0.09;0.24) | 0.001 (−0.13;0.13) | −0.11 (−0.23;0.01) | 0.002 (−0.16;0.16) | 0.02 (−0.16;0.20) | −0.05 (−0.23;0.14) | 0.04 (−0.14;0.21) |
| Single | 73 | 0.002 (−0.16;0.16) | 0.09 (−0.11;0.29) | 0.12 (−0.09;0.33) | 0.09 (−0.07;0.25) | −0.05 (−0.20;0.11) | −0.05 (−0.25;0.15) | −0.001 (−0.23;0.22) | −0.15 (−0.40;0.10) | 0.10 (−0.13;0.32) |
| 2–4 | 29 | 0.01 (−0.25;0.27) | 0.21 (−0.11;0.53) | 0.19 (−0.16;0.53) | 0.0004 (−0.26;0.26) | −0.23 (−0.48;0.03) | 0.31 (−0.02;0.63) | 0.14 (−0.23;0.51) | 0.12 (−0.29;0.53) | 0.26 (−0.10;0.63) |
| >4 | 21 | −0.31 (−0.63;0.01) | −0.18 (−0.57;0.22) | −0.28 (−0.71;0.14) | −0.35 (−0.66;−0.03) | −0.19 (−0.50;0.12) | −0.23 (−0.63;0.17) | −0.06 (−0.51;0.39) | −0.11 (−0.61;0.39) | −0.61 (−1.05;−0.17) |
Values represent mean differences in Z-score of various cognitive tests in those with microbleeds compared to those without microbleeds.
Values are adjusted for age, sex, education level, baseline cognitive tests score, and time between baseline and follow-up visit.
*
Lobar microbleeds with or without cerebellar microbleeds.
±
Deep or infratentorial microbleeds with or without lobar microbleeds.