Fig. 4.

A: Monthly assessment of glomerular filtration rate (GFR) was performed for 6 mo after diabetes induction. GFR was evaluated using a transcutaneous detector after a single intravenous bolus of FITC-sinistrin. Values represent means ± SE; n = 4–8. B: 24-h albuminuria excretion at baseline and after 4 and 6 mo of diabetes. C: renal expression of megalin was assessed in total kidney homogenate by Western blot. *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001 vs. nondiabetic control. Non-d, nondiabetic.