Table 1.
Renal phenotype 6 mo after induction of diabetes
| Wild-Type |
it-ACE |
ACE 3/9 |
||||
|---|---|---|---|---|---|---|
| Characteristic | Nondiabetic | Diabetic | Nondiabetic | Diabetic | Nondiabetic | Diabetic |
| Body weight, g | 31.2 ± 1.5 | 26.7 ± 1.0a | 30.2 ± 0.8 | 26.9 ± 0.7 | 31.4 ± 1.1 | 25.7 ± 0.8b |
| Kidney weight, mg | 177.2 ± 9.0 | 207.5 ± 10.5 | 181.8 ± 6.8 | 190.4 ± 9.4 | 167.5 ± 5.1 | 191.6 ± 9.0 |
| Kidney weight/body weight, mg/g | 5.7 ± 0.2 | 7.5 ± 0.2c | 6.1 ± 0.1 | 6.9 ± 0.3 | 5.3 ± 0.1 | 7.5 ± 0.3c |
| Urinary volume, ml/day | 2.5 ± 0.4 | 17.0 ± 2.1b | 3.1 ± 0.4 | 14.7 ± 2.8b | 3.3 ± 0.5 | 19.7 ± 2.7c |
| Urine osmolality, mosmol/kgH2O | 2.9 ± 0.5 | 12.5 ± 2.8c | 3.0 ± 0.3 | 11.8 ± 1.5c | 3.5 ± 0.9 | 13.9 ± 1.0c |
| Urinary glucose, mg/day | N.D. | 132 ± 12 | N.D. | 129 ± 13 | N.D. | 137 ± 14 |
Values represent means ± SE. N.D., not detected.
a
P < 0.05 vs. respective nondiabetic control.
b
P < 0.01 vs. respective nondiabetic control.
c
P < 0.001 vs. respective nondiabetic control.