Fig. 11.
Effects of Gö6983 and myxothiazol on contractions to 10 and 30 μM Na2S. A: Amplitude of contractions evoked by two successive applications of 10 or 30 μM Na2S in the presence of 5 μM PGF2α under control conditions (time controls) and when Gö6983 (3 μM) or myxothiazol (1 μM) was added to the bath 30 min before the second application of sulfide. *P < 0.05, significant difference between the contractions observed during the 1st and 2nd applications of sulfide. B: concentration-dependent contraction caused by the sulfide “donor” l-cysteine in PGF2α-preconstricted arteries under control conditions and in the presence of Gö6983 (3 μM) or myxothiazol (1 μM). *P < 0.05, significantly different from the corresponding control value for that phase.