Fig. 8.

Attenuation of capillary morphogenesis of PEDF^−/− ChECs. A: ChECs express PEDF receptors. ChECs expressed similar levels of PEDF receptors, PEDFR and laminin B receptor, independent of PEDF expression. B: PEDF^−/− ChECs fail to undergo capillary morphogenesis in Matrigel. Images were captured in digital format after 14 h in culture (scale bar = 50 µm in upper panels and 100 µm in lower panels). There was a significant decrease in capillary morphogenesis of PEDF^−/− ChECs compared with PEDF^+/+ cells (*P < 0.05, n = 3).