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PEDF deficiency does not affect the downstream Akt and MAPK signaling pathways. The activation of MAPK and Akt pathways were evaluated by Western blot analysis using specific antibodies as detailed in materials and methods. No significant changes in these pathways were detected in PEDF−/− ChECs compared with PEDF+/+ cells. These experiments were repeated with two different isolations of ChECs with similar results (n ≥ 3).
