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. 2018 May 23;38(21):4846–4858. doi: 10.1523/JNEUROSCI.3349-17.2018

Figure 4.

Figure 4.

DA-induced morphological changes depend on activation of D1-like and D2-like DA receptors. A, Representative images of GFAP+ astrocytes after a 1 h exposure to DA (75 μm) or after exposure to DA in the presence of D1-like DA receptor antagonist SCH23390 (50 μm; DA + SCH), D2-like DA receptor antagonist, sulpiride (20 μm; DA + Sulp), or DA with the IP3 receptor antagonist, 2-APB (50 μm; DA + 2-APB). Scale bars, 75 μm. B, Quantification of number of primary processes and average GFAP+ cell area. One-way ANOVA for number of processes (F(5,502) = 14.15, p < 0.0001). One-way ANOVA for GFAP area (F(5,503) = 1.777, p = 0.1160). Bonferroni post hoc: *p < 0.05 versus control. ***p < 0.001 versus control. #p < 0.05 versus DA. ##p < 0.01 versus DA. ###p < 0.001 versus DA. Control, n = 105 cells; DA, n = 116 cells; DA + SCH, n = 84 cells; DA + Sulp, n = 70 cells; DA + SCH + Sulp, n = 84 cells; DA + 2-APB, n = 50 cells.